Adjuvant therapies

Adjuvant techniques and therapies


Some adjuvant therapies and techniques are effective in particular situations.

In the case of others, the use is empirical, being insufficiently studied or controversial.

There is an extremely wide range of complementary techniques and therapies, both drugs and laboratory techniques or interventional procedures that aim to improve the chances of success.

Adjuvant therapies for ovarian stimulation

  • Growth hormone – possible benefit after 40 years
  • Androgens: testosterone, DHEA – for follicular recruitment
  • Estrogens – priming for the synchronization of ovarian follicles
  • Corticosteroids – in associated immunological diseases
  • Anticoagulants – in ovarian hyperstimulation syndrome
  • Coenzyme Q10 – supplement for cellular energy
  • Melatonin
  • Antioxidants
  • Aspirin – uncertain benefits
  • Vasodilators – Nitroglycerin, Sildenafil – blurred effect
  • Intravenous immunoglobulins – uncertain benefits
  • Intralipid infusion – unclear effects, associated risks
  • Cabergoline – reducing the risk of complications

Adjuvant laboratory techniques

P-ICSI (Physiological ICSI) – A variant of the ICSI technique

Especially useful for sperm morphology problems

Sperm selection is done with the help of special media
Sperm activation with SpermMobil

Used in the case of immobile sperm, to select viable ones

Assisted hatching

The embryologist makes a gap in the membrane of the embryo

Useful when the embryo has a thick, dense membrane (area)

Assisted oocyte activation with Calcium ionophore

Used in case of fertilization failure after ICSI

Oocytes are prepared with media that help fertilize


Medium used in embryo transfer

It could help implant in particular cases

Support techniques for implantation

Endometrial activation with G-CSF granulocyte growth factors

It would help the growth of the thin endometrium, a controversial benefit

Endometrial microabrasion – Endometrial microinjury

The inflammatory reaction would facilitate implantation, a controversial benefit

  • Intrauterine lavage with HCG – controversial benefit
  • PRP (Platelet Rich Plasma) therapy – experimental, uncertain benefit
  • Atosiban infusion – reduces uterine contractility

Alternative therapies

Alternative techniques aim to balance the whole body, at the energy and emotional level

  • Acupuncture
  • Yoga
  • Mental or holistic therapies